Cellular immunity to possible synovial antigens in rheumatoid arthritis.

Cellular immunity to possible synovial antigens in rheumatoid arthritis.

A reaction has been demonstrated between extracts of synovial cells removed from intact rheumatoid knee joints and autologous leucocytes. The cell mediated immunity test system used was leucocyte migration inhibition. Variable reactions were found with a spectrum of allogeneic extracts when donor leucocytes came from married or transfused females or transfused males. Leucocytes from healthy (no...

Synovial hyaluronate in rheumatoid arthritis

Acute inflammation of joints can lead to the development of chronic arthritis. The nature of agents that sustain the chronic inflammation remains an enigma, although infectious agents such as Rubella virus, Epstein-Barr virus or Chlamydia have been invoked. In most cases in which an inducing agent was sought, none was found.' However, several antigens have been identified that elicit acute arth...

Synovial activation in rheumatoid arthritis.

Rheumatoid arthritis (RA) is a chronic inflammatory disease with progressive articular damage. Activated cells of the synovium produce pro-inflammatory and matrix-degrading effector molecules, which maintain the inflammation and lead to the destruction of the involved joints. In addition to macrophages and T- and B-cells, fibroblast-like synoviocytes must be considered key cells in driving the ...

Identification of bacterial antigens and super antigens in synovial fluid of patients with arthritis: a cross sectional study

  Background : An accurate and prompt diagnosis of bacterial arthritis is essential for earlier treatment and a good outcome. Superantigens produced by Staph. Aureus are among the most lethal toxins. The paper objective was Identification of common bacterial antigens and S.aureus superantigens in synovial fluid (SF) of children with negative culture and direct smear for other bacteria except fo...

Rheumatoid Arthritis Synovial Stromal Cells